Catalog Number: 3633
Alternate Names: AMPCP, APCP
Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt
Biological Activity
Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
Technical Data
  • M.Wt:
    447.21
  • Formula:
    C11H16N5NaO9P2
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    89016-30-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
    Niemelä et al.
    Eur.J.Immunol., 2008;38:2718
  2. Purinergic control of vascular tone in the retina.
    Kur et al.
    J.Physiol., 2014;592:491
  3. Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.
    Ujházy et al.
    Int.J.Cancer., 1996;68:493
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:

1 Citations: Showing 1 - 1

  1. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
    Authors: Caiazzo Et al.
    Biochem.Pharmacol. 2016;112:72

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