Adenosine 5'-(α,β-methylene)diphosphate sodium salt
Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt
Purity: ≥98%
Biological Activity
Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
Niemelä et al.
Eur.J.Immunol., 2008;38:2718 -
Purinergic control of vascular tone in the retina.
Kur et al.
J.Physiol., 2014;592:491 -
Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.
Ujházy et al.
Int.J.Cancer., 1996;68:493 -
Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats.
Chen et al.
ACS Chem.Neurosci., 2019;10:2809
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Citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:
2 Citations: Showing 1 - 2
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Borneol and α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors.
Authors: Wu Et al.
Drug Deliv 2018;25:1858
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Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Authors: Caiazzo Et al.
Biochem.Pharmacol. 2016;112:72
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