Adenosine 5'-(α,β-methylene)diphosphate sodium salt
Chemical Name: α,β-Methyleneadenosine 5'-diphosphate monosodium salt
Biological ActivityAdenosine 5'-(α,β-methylene)diphosphate sodium salt is an Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
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IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
Niemelä et al.
Purinergic control of vascular tone in the retina.
Kur et al.
Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.
Ujházy et al.
Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats.
Chen et al.
ACS Chem.Neurosci., 2019;10:2809
Citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:
2 Citations: Showing 1 - 2
Borneol and α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors.
Authors: Wu Et al.
Drug Deliv 2018;25:1858
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Authors: Caiazzo Et al.
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