ADX 10059 hydrochloride
Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Biological ActivityReported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
Weiss et al.
A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.
Keywood et al.
Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?
Marin and Goadsby
Expert Opin.Invest.Drugs, 2010;19:555
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