Catalog Number: 4416
Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Biological Activity
Reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
    Weiss et al.
    Bioorg.Med.Chem.Lett., 2011;21:4891
  2. A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.
    Keywood et al.
    Gut., 2009;58:1192
  3. Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?
    Marin and Goadsby
    Expert Opin.Invest.Drugs, 2010;19:555

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