ADX 10059 hydrochloride

Key Product Details

Product Description

ADX 10059 hydrochloride is reported to be a negative allosteric modulator at the mGlu₅ receptor. Analog of MPEP (Cat. No. 1212).

Product Specifications for ADX 10059 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ADX 10059 hydrochloride

The following data is based on the product molecular weight 276.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.07 mL	36.14 mL
5 mM	0.72 mL	3.61 mL	7.23 mL
10 mM	0.36 mL	1.81 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Keywood A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 2009 PMID: 19460767
• Marin and Goadsby Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 2010 PMID: 20218930
• Weiss 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 2011 PMID: 21757343

Product Documents for ADX 10059 hydrochloride