AF 12198

Tocris Bioscience | Catalog # 1793

Potent, selective human type I IL-1 receptor antagonist
Tocris Bioscience

Key Product Details

Description

Potent, selective human type I IL-1 receptor antagonist
View all Cytokine Receptor Antagonists »

Product Description

AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Product Specifications for AF 12198

Molecular Weight

1895.14

Formula

C96H123N19O22

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

185413-30-3

PubChem ID

90488713

InChI Key

VASLMBMCJADVGR-BRPRRQPRSA-N

SMILES

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in 10% ethanol/PBS

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for AF 12198

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AF 12198

For research use only

Customer Reviews for AF 12198 (1)

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  • ICD-related studies
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    The antagonist for the human type I interleukin-1 (IL-1) receptor was used in studies exploring immunogenic cell death induced by chemotherapeutics. Results were consistent.

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