AF 12198

Catalog # Availability Size / Price Qty
1793/1
AF 12198
1 Image
Description: Potent, selective human type I IL-1 receptor antagonist
Product Details
Citations (1)
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Biological Activity

Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Technical Data

M.Wt:
1895.14
Formula:
C96H123N19O22
Sequence:
FEWTPGWYQXYALPL

(Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 10% ethanol/PBS
Storage:
Desiccate at -20°C
CAS No:
185413-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AF 12198

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