IL-1 RI, also known as the type 1 IL-1 receptor and CD121a, is a transmembrane protein in the Toll/IL-1 R (TIR) superfamily. IL-1 RI binds the pleiotropic cytokines IL-1 alpha and IL-1 beta, plus the IL-1 receptor antagonist (IL-1 Ra). Signal transduction requires complex formation with IL-1 R AcP/IL-1 R3. This complex recruits the adaptor protein MyD88, to initiate signaling in the NF kappa B pathway. IL-1 RI is expressed predominantly by T cells, fibroblasts, and endothelial cells and mediates acute phase inflammatory responses including fever.
Mouse IL-1 RI (NP_032388) VersaClone cDNA
R&D Systems | Catalog # RDC1515
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Background: IL-1 RI
Long Name
Interleukin 1 Receptor I
Alternate Names
CD121a, IL-1RI, IL1R1, IL1RI
Gene Symbol
IL1R1
UniProt
Additional IL-1 RI Products
Product Documents for Mouse IL-1 RI (NP_032388) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Mouse IL-1 RI (NP_032388) VersaClone cDNA
For research use only
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Associated Pathways
