Human IL-1 beta/IL-1F2 (AAA36106) VersaClone cDNA

Human IL-1 beta/IL-1F2 (AAA36106) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: IL-1 beta/IL-1F2

IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.

Related Research Areas

• Alpha Granule Soluble Molecules
• Cancer Biomarkers
• Conventional/Classical Dendritic Cells
• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Angiogenesis
• IL-1 Family
• Infectious Diseases
• Inflammatory Mediators
• Isolation, Culture, and Identification of Natural Killer Cells
• LTi Cells
• Macrophage Activation Markers
• Microglia Activation Markers
• Multiple Sclerosis and Myelin Related Molecules
• Myeloid-derived Suppressor Cells (MDSC)
• NCR-ILC3
• Neuroinflammatory Factors
• NOD-like Receptors and the Inflammasome
• Regulatory T Cells (Tregs)
• Search Cytokine and Growth Factor Products
• T Cell Cytokine Signaling
• Th17 Cells
• Th9 Cells