Biological ActivityPotent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
(Modifications: Disulfide bridge between 7 - 16)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.
Bednarek et al.
Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2.
Gao et al.
Citation for [Ala17]-MCH
The citations listed below are publications that use Tocris products. Selected citations for [Ala17]-MCH include:
1 Citation: Showing 1 - 1
Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
Authors: Camp Et al.
Pharmacol Res 2016;105:13
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