Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride
Biological ActivityAlexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.
Yip et al.
Mol.Cancer Ther., 2006;5:2234
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
Doughty-Shenton et al.
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
Liu et al.
Citation for Alexidine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Alexidine dihydrochloride include:
1 Citation: Showing 1 - 1
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
Authors: Niemi Et al.
PLoS One 2013;8:e53803
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