Catalog Number: 3979
Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride
Biological Activity
Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.
    Yip et al.
    Mol.Cancer Ther., 2006;5:2234
  2. Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
    Doughty-Shenton et al.
    J.Pharmacol.Exp.Ther., 2010;333:584
  3. Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
    Liu et al.
    Blood, 2015;125:1562
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