Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50
= 1.08 μ
M in vitro
). Stimulates increased insulin secretion by β
-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo
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All Tocris products are intended for laboratory research use only.
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.
Yip et al.
Mol.Cancer Ther., 2006;5:2234
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
Doughty-Shenton et al.
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
Liu et al.