Alexidine dihydrochloride

Key Product Details

Product Description

Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC₅₀ = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Product Specifications for Alexidine dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Alexidine dihydrochloride

The following data is based on the product molecular weight 581.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.60 mL	17.19 mL
5 mM	0.34 mL	1.72 mL	3.44 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Doughty-Shenton Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 2010 PMID: 20167843
• Liu Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 2015 PMID: 25593337
• Yip Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 2006 PMID: 16985057

Product Documents for Alexidine dihydrochloride