Alfuzosin hydrochloride

Tocris Bioscience | Catalog # 3305

Uroselective α1 antagonist
Tocris Bioscience
Discontinued Product
3305 has been discontinued. View all Adrenergic alpha-1 Receptor Antagonists products.

Key Product Details

Description

Uroselective α1 antagonist
View all Adrenergic alpha-1 Receptor Antagonists »

Product Description

Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.

Product Specifications for Alfuzosin hydrochloride

Molecular Weight

425.91

Formula

C19H27N5O4.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride

CAS Number

81403-68-1

PubChem ID

71764

InChI Key

YTNKWDJILNVLGX-UHFFFAOYSA-N

SMILES

NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.65 25
DMSO 10.65 25

Preparing Stock Solutions for Alfuzosin hydrochloride

The following data is based on the product molecular weight 425.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.39 mL 46.96 mL 93.92 mL
1.25 mM 1.88 mL 9.39 mL 18.78 mL
2.5 mM 0.94 mL 4.70 mL 9.39 mL
12.5 mM 0.19 mL 0.94 mL 1.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Alfuzosin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Alfuzosin hydrochloride

For research use only

Customer Reviews for Alfuzosin hydrochloride (1)

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  • Used to investigate cell metabolism
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 02/27/2023
    The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.

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