Functionally uro-selective α1
adrenoceptor antagonist that does not discriminate between α1
subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50
= 7.64) in vitro
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Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum.
Palea and Barras
BJU Int., 2003;91:873
Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia.
Am.J.Health Syst.Pharm., 2003;60:1426
Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes.
Yamaguchi et al.
J.Smooth Muscle Res., 2005;41:247