Catalog Number: 3305
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Biological Activity
Functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.
Technical Data
  • M.Wt:
    425.91
  • Formula:
    C19H27N5O4.HCl
  • Solubility:
    Soluble to 25 mM in water and to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    81403-68-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum.
    Palea and Barras
    BJU Int., 2003;91:873
  2. Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia.
    Lee
    Am.J.Health Syst.Pharm., 2003;60:1426
  3. Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes.
    Yamaguchi et al.
    J.Smooth Muscle Res., 2005;41:247

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