AMG 21629

Key Product Details

Product Description

AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca²⁺ uptake by CHO cells expressing TRPV1 receptors (IC₅₀ values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca²⁺ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

Product Specifications for AMG 21629

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AMG 21629

The following data is based on the product molecular weight 472.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.23 mL	21.17 mL	42.34 mL
2.5 mM	0.85 mL	4.23 mL	8.47 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
25 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Gavva The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J.Neurosci. 2007 PMID: 17392452
• Tamayo Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J.Med.Chem. 2008 PMID: 18386885

Product Documents for AMG 21629