Prototypic vanilloid receptor agonist (pEC50
values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™
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All Tocris products are intended for laboratory research use only.
Cannabinoid activation of recombinant and endogenous vanilloid receptors.
Ralevic et al.
Sensory neuron-specific actions of capsaicin: mechanisms and application.
Bevan and Szolcsani
Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons.
Hogaboam and Wallace
Capsaicin-cellular targets, mechanism of actions, and selectivity for thin sensory neurons.
The citations listed below are publications that use Tocris products. Selected citations for (E)-Capsaicin include:
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