Chemical Name: (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Biological Activity(E)-Capsaicin is a prototypic vanilloid receptor agonist (pEC50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Sensory neuron-specific actions of capsaicin: mechanisms and application.
Bevan and Szolcsani
Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons.
Hogaboam and Wallace
Capsaicin-cellular targets, mechanism of actions, and selectivity for thin sensory neurons.
Cannabinoid activation of recombinant and endogenous vanilloid receptors.
Ralevic et al.
Citations for (E)-Capsaicin
The citations listed below are publications that use Tocris products. Selected citations for (E)-Capsaicin include:
38 Citations: Showing 1 - 10
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
Authors: Diniz Et al.
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
Authors: Balleza-Tapia Et al.
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
Authors: Yissachar Et al.
Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.
Authors: Chen Et al.
Sci Rep 2016;6:33307
Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers.
Authors: Zakharov Et al.
J Transl Med 2015;9:287
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Front Cell Neurosci 2015;21:4852
Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/κ-opioid system and transient receptor potential vanilloid type-1 ion channel.
Authors: Wang Et al.
PLoS One 2015;13:284
Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.
Authors: Ma Et al.
Mol Pain 2015;11:22
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
Authors: Chen Et al.
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
Authors: Stanley Et al.
Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53.
Authors: Rossi Et al.
Mol Neurodegener 2014;9:56
Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
Authors: Nguyen Et al.
Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
Authors: Wang Et al.
Am J Physiol Gastrointest Liver Physiol 2014;307:G719
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Authors: Chen Et al.
Mol Pain 2014;20:1298
Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
Authors: Fairless Et al.
PLoS One 2013;8:e58260
Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
Authors: Nesuashvili Et al.
Mol Pharmacol 2013;83:1007
Bacteria activate sensory neurons that modulate pain and inflammation.
Authors: Chiu Et al.
World J Gastroenterol 2013;501:52
Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Authors: Shabir Et al.
Development and experimental application of an HPLC procedure for the determination of capsaicin and dihydrocapsaicin in serum samples from human subjects.
Authors: Hartley Et al.
Indian J Clin Biochem 2013;28:329
Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
Authors: Gao Et al.
Acta Neurochir Suppl 2012;61:1381
7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersen
Authors: Nash Et al.
J Pharmacol Exp Ther 2012;342:389
Increase of capsaicin-induced trigeminal Fos-like immunoreactivity by 5-HT(7) receptors.
Authors: Martínez-García Et al.
Cardiovasc Res 2011;51:1511
Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
Authors: Zsombok Et al.
Exp Neurol 2011;31:14024
Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats.
Authors: Khatibi Et al.
Mol Pain 2011;111:225
A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.
Authors: Cobellis Et al.
Biol Reprod 2010;82:451
Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.
Authors: Westlund Et al.
Proc Natl Acad Sci U S A 2010;6:46
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Authors: Buznikov Et al.
Dev Neurosci 2010;32:1
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Authors: Bhaskaran and Smith
World J Gastroenterol 2010;223:529
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice.
Authors: Benninger Et al.
Br J Pharmacol 2008;52:89
Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia.
Authors: Pitcher Et al.
J Pharmacol Exp Ther 2007;3:17
Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.
Authors: Ahern Et al.
J Neurosci 2005;25:5109
Pungent products from garlic activate the sensory ion channel TRPA1.
Authors: Bautista Et al.
Br J Pharmacol 2005;102:12248
Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-α-mediated apoptotic liver damage.
Authors: Bang Et al.
J Neurosci 2004;308:1174
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors.
Authors: Melis Et al.
J Neurosci 2004;24:53
'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.
Authors: Smart Et al.
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Authors: Craib Et al.
Neurochem Int 2001;134:42581
Effect of vanilloid drugs on gastrointestinal transit in mice.
Authors: Izzo Et al.
Br J Pharmacol 2001;132:1411
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