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Anti-PAR Monoclonal Antibody

Catalog #: 4335-MC-01K-AC
3 Citations Datasheet / COA / SDS

Discontinued Product

4335-MC-01K-AC has been discontinued.
View all PAR/pADPr products.
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Citations (3)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Anti-PAR Monoclonal Antibody Summary

Source
Monoclonal Clone # 10HA
Label
Unconjugated
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

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Citations for Anti-PAR Monoclonal Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance
    Authors: W Jdey, M Kozlak, S Alekseev, S Thierry, P Lascaux, PM Girard, F Bono, M Dutreix
    Neoplasia, 2019-07-27;21(9):863-871.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ELISA Capture
  2. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.
    Authors: Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp M
    Mol Cell Biol, 2012-12-10;33(4):845-57.
  3. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.
    Authors: Jaspers J, Kersbergen A, Boon U, Sol W, van Deemter L, Zander S, Drost R, Wientjens E, Ji J, Aly A, Doroshow J, Cranston A, Martin N, Lau A, O'Connor M, Ganesan S, Borst P, Jonkers J, Rottenberg S
    Cancer Discov, 2012-10-25;3(1):68-81.

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