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Anti-PAR Monoclonal Antibody w/Control

Catalog #: 4335-MC-100-AC
4 Citations Datasheet / COA / SDS

Discontinued Product

4335-MC-100-AC has been discontinued.
View all PAR/pADPr products.
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Citations (4)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Anti-PAR Monoclonal Antibody w/Control Summary

Source
Monoclonal Clone # 10HA
Label
Unconjugated
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

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Citations for Anti-PAR Monoclonal Antibody w/Control

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
    Authors: N Zhang, Y Zhang, H Qian, S Wu, L Cao, Y Sun
    Cell Death Differ., 2020-03-05;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia
    Authors: S Kannan, MJL Aitken, SM Herbrich, LS Golfman, MG Hall, DH Mak, JK Burks, G Song, M Konopleva, CG Mullighan, J Chandra, PA Zweidler-M
    Mol. Cancer Ther., 2019-06-21;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  3. Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts.
    Authors: Bhardwaj V, Horvat A, Korolkova O, Washington M, El-Rifai W, Dikalov S, Zaika A
    Carcinogenesis, 2016-09-21;37(12):1161-1169.
  4. Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of beta -Catenin Degradation-Competent Axin Puncta
    Authors: Estefania Martino-Echarri, Mariana G. Brocardo, Kate M. Mills, Beric R. Henderson
    PLOS ONE
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation

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