AP 24534

Catalog # Availability Size / Price Qty
4274/10
4274/50
Abl Kinase Inhibitors Small Molecule
1 Image
Description: Potent multi-kinase and pan-Bcr-Abl inhibitor
Alternative Names: Ponatinib

Chemical Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

Purity: ≥98%

Product Details
Citations (3)
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Reviews

Biological Activity

Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active.

Technical Data

M.Wt:
532.56
Formula:
C29H27F3N6O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
943319-70-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AP 24534

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3 Citations: Showing 1 - 3

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