AP 24534

  ( 1 citations )    
Product Datasheet
Catalog Number:4274
Alternate Names:Ponatinib
Chemical Name:3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active.
Technical Data
  • M.Wt:
    532.56
  • Formula:
    C29H27F3N6O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    943319-70-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AP 24534 include:

1 Citations: Showing 1 - 1

  1. Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin.
    Authors: Wong Et al.
    Cancer Biol Ther  2013;14:56

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