Selective galanin GAL2
receptor agonist (IC50
values are 1.76 and 879 nM for GAL2
respectively). Also shows moderate affinity for GAL3
values are 88 and 271 nM for GAL2
respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling.
Mazarati et al.
Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.
Lu et al.
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Liu et al.
Proc.Natl.Acad.Sci USA, 2001;98:9960