Catalog Number: 2699
Alternate Names: Gal(2-11)amide
Biological Activity
Selective galanin GAL2 receptor agonist (IC50 values are 1.76 and 879 nM for GAL2 and GAL1 respectively). Also shows moderate affinity for GAL3 receptors (Ki values are 88 and 271 nM for GAL2 and GAL3 respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Leu-10 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% formic acid
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling.
    Mazarati et al.
    J.Pharmacol.Exp.Ther., 2006;318:700
  2. Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.
    Lu et al.
    Neuropeptides, 2005;39:165
  3. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
    Liu et al.
    Proc.Natl.Acad.Sci USA, 2001;98:9960
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