[Arg¹⁴,Lys¹⁵]Nociceptin

Name: [Arg 14 ,Lys 15 ]Nociceptin
Brand: Tocris Bioscience
SKU: 1590

Tocris Bioscience | Catalog # 1590

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Citations (4)

Product Documents

Highly potent and selective NOP agonist

Discontinued Product

1590 has been discontinued. View all NOP Receptor Agonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Highly potent and selective NOP agonist

View all NOP Receptor Agonists »

Product Description

[Arg¹⁴,Lys¹⁵]Nociceptin is a highly potent and selective NOP receptor agonist (EC₅₀ = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC₅₀ values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

Product Specifications for [Arg¹⁴,Lys¹⁵]Nociceptin

Molecular Weight

1909.18

Formula

C₈₂H₁₃₇N₃₁O₂₂

Storage

Desiccate at -20°C

CAS Number

236098-40-1

PubChem ID

16143911

InChI Key

VULLMZOQBGUKAT-VUXBHJHDSA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Okada Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 2000 PMID: 11097863
Rizzi [Arg¹⁴,Lys¹⁵]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 2002 PMID: 11752097
Calo Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 2002 PMID: 11906488

Product Documents for [Arg¹⁴,Lys¹⁵]Nociceptin

Certificate of Analysis

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Product Specific Notices for [Arg¹⁴,Lys¹⁵]Nociceptin

For research use only

Related Research Areas

Neurotransmitter G Protein-Coupled Receptors

Citations for [Arg¹⁴,Lys¹⁵]Nociceptin

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