Catalog Number: 1590
Biological Activity
Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
Technical Data
  • M.Wt:
    1909.18
  • Formula:
    C82H137N31O22
  • Sequence:
    FGGFTGARKSARKRKNQ
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    236098-40-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological profile of nociceptin/orphanin FQ receptors.
    Calo et al.
    Clin.Exp.Pharmacol.Physiol., 2002;29:223
  2. [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.
    Rizzi et al.
    J.Pharmacol.Exp.Ther., 2002;300:57
  3. Highly potent nociceptin analog containing the Arg-Lys triple repeat.
    Okada et al.
    Biochem.Biophys.Res.Commun., 2000;278:493
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:

1 Citations: Showing 1 - 1

  1. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
    Authors: Kuzmin Et al.
    Br J Pharmacol 2004;141:132

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