Discontinued Product

1590 has been discontinued.
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Description: Highly potent and selective NOP agonist
Product Details
Citations (1)

Biological Activity

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological profile of nociceptin/orphanin FQ receptors.
    Calo et al.
    Clin.Exp.Pharmacol.Physiol., 2002;29:223
  2. Highly potent nociceptin analog containing the Arg-Lys triple repeat.
    Okada et al.
    Biochem.Biophys.Res.Commun., 2000;278:493
  3. [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.
    Rizzi et al.
    J.Pharmacol.Exp.Ther., 2002;300:57

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for [Arg14,Lys15]Nociceptin

The citations listed below are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:

1 Citation: Showing 1 - 1


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