Biological ActivityHighly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological profile of nociceptin/orphanin FQ receptors.
Calo et al.
Highly potent nociceptin analog containing the Arg-Lys triple repeat.
Okada et al.
[Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.
Rizzi et al.
Citation for [Arg14,Lys15]Nociceptin
The citations listed below are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:
1 Citation: Showing 1 - 1
Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
Authors: Kuzmin Et al.
Br J Pharmacol 2004;141:132
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