Catalog Number: 2621
Chemical Name: 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
Biological Activity
Selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
Technical Data
  • M.Wt:
    364.42
  • Formula:
    C17H20N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    704888-90-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).
    Rossello et al.
    Bioorg.Med.Chem., 2004;12:2441
  2. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides.
    Tuccinardi et al.
    Bioorg.Med.Chem., 2006;14:4260
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ARP 100 include:

2 Citations: Showing 1 - 2
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  1. Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice.
    Authors: Hensley Et al.
    Neoplasia 2012;14:451
  2. MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.
    Authors: Chetty Et al.
    Mol Biol Cell 2010;127:1081

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