Selective inhibitor of MMP-2 (IC50
= 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50
values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
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All Tocris products are intended for laboratory research use only.
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).
Rossello et al.
Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides.
Tuccinardi et al.
The citations listed below are publications that use Tocris products. Selected citations for ARP 100 include:
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