Potent and selective inhibitor of PI 3-kinase γ
= 8 nM). Displays 30-fold selectivity over PI 3-Kδ
and PI 3-Kβ
and 7.5-fold selectivity over PI 3-Kα
. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
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Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
Peng et al.
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Camps et al.
Nature Med., 2005;11:936
The citations listed below are publications that use Tocris products. Selected citations for AS 605240 include:
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