Home / PI 3-Kinase Inhibitors / AS 605240

AS 605240

Catalog #: 3578
2 Citations Datasheet / COA / SDS

Discontinued Product

3578 has been discontinued.
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AS 605240 | CAS No. 648450-29-7 | PI 3-Kinase Inhibitors
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Description: Potent and selective PI 3-kinase γ (PI 3-Kγ) inhibitor

Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AS 605240 is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Technical Data

M.Wt:
257.27
Formula:
C12H7N3O2S
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
648450-29-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
    Peng et al.
    J.Pharmacol.Exp.Ther., 2010;332:46
  2. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
    Camps et al.
    Nature Med., 2005;11:936
  3. Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
    Wang et al.
    Biochem.Biophys.Res.Comm., 2009;386:569

Product Datasheets

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Citations for AS 605240

The citations listed below are publications that use Tocris products. Selected citations for AS 605240 include:

2 Citations: Showing 1 - 2

  1. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
    Authors: Schepetkin Et al.
    Mol Pharmacol  2012;81:832
  2. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.
    Authors: Beauséjour Et al.
    Apoptosis  2012;17:566

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