AS 605240

Catalog # Availability Size / Price Qty
3578/10
3578/50
AS 605240 | CAS No. 648450-29-7 | PI 3-Kinase Inhibitors
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Description: Potent and selective PI 3-kinase γ (PI 3-Kγ) inhibitor

Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Technical Data

M.Wt:
257.27
Formula:
C12H7N3O2S
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
648450-29-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
    Peng et al.
    J.Pharmacol.Exp.Ther., 2010;332:46
  2. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
    Camps et al.
    Nature Med., 2005;11:936
  3. Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
    Wang et al.
    Biochem.Biophys.Res.Comm., 2009;386:569

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Citations for AS 605240

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