Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Biological ActivityAS 605240 is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
Peng et al.
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Camps et al.
Nature Med., 2005;11:936
Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
Wang et al.
Citations for AS 605240
The citations listed below are publications that use Tocris products. Selected citations for AS 605240 include:
2 Citations: Showing 1 - 2
Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
Authors: Schepetkin Et al.
Mol Pharmacol 2012;81:832
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.
Authors: Beauséjour Et al.
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