Catalog Number: 3578
Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Biological Activity
Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
Technical Data
  • M.Wt:
    257.27
  • Formula:
    C12H7N3O2S
  • Solubility:
    Soluble to 1 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    648450-29-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
    Peng et al.
    J.Pharmacol.Exp.Ther., 2010;332:46
  2. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
    Camps et al.
    Nature Med., 2005;11:936
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AS 605240 include:

2 Citations: Showing 1 - 2
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  1. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
    Authors: Schepetkin Et al.
    Mol Pharmacol 2012;81:832
  2. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.
    Authors: Beauséjour Et al.
    Apoptosis 2012;17:566

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