AS 605240

Key Product Details

Product Description

AS 605240 is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC₅₀ = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Product Specifications for AS 605240

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AS 605240

The following data is based on the product molecular weight 257.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	388.70 mL	1,943.48 mL	3,886.97 mL
0.05 mM	77.74 mL	388.70 mL	777.39 mL
0.1 mM	38.87 mL	194.35 mL	388.70 mL
0.5 mM	7.77 mL	38.87 mL	77.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Camps Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Med.
• Wang Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem.Biophys.Res.Comm.
• Peng Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J.Pharmacol.Exp.Ther. 2010 PMID: 19828878

Product Documents for AS 605240