Ascomycin

   
Product Datasheet
Catalog Number:4210
Alternate Names:FK 520, FR 900520
Chemical Name:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-py
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Biological Activity
Analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.
Technical Data
  • M.Wt:
    792.01
  • Formula:
    C43H69NO12
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    104987-12-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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