Catalog Number: 4210
Alternate Names: FK 520, FR 900520
Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-py
Biological Activity
Analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.
Technical Data
  • M.Wt:
    792.01
  • Formula:
    C43H69NO12
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    104987-12-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
    Motamedi et al.
    J.Bacteriol., 1996;178:5243
  2. Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.
    Arndt et al.
    Microbiology, 1999;145:1989
  3. Genetically engineered analogs of ascomycin for nerve regeneration.
    Revill et al.
    J.Pharmacol.Exp.Ther., 2002;302:1278
  4. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics.
    Hatanaka et al.
    J.Antibiot (Tokyo)., 1988;41:1593
Tocris Small Molecules
Description Application Cat# Citations Images  

FK 506

3631 11  
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