Ascomycin

Tocris Bioscience | Catalog # 4210

Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
Tocris Bioscience
Discontinued Product
4210 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description

Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)

Alternative Names

FK 520,FR 900520
View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Ascomycin is a analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.

Product Specifications for Ascomycin

Molecular Weight

792.01

Formula

C43H69NO12

Storage

Store at -20°C

Chemical Name

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

CAS Number

104987-12-4

PubChem ID

5282071

InChI Key

ZDQSOHOQTUFQEM-NURRSENYSA-N

SMILES

O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.6 50
Ethanol 39.6 50

Preparing Stock Solutions for Ascomycin

The following data is based on the product molecular weight 792.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.53 mL 12.63 mL 25.25 mL
2.5 mM 0.51 mL 2.53 mL 5.05 mL
5 mM 0.25 mL 1.26 mL 2.53 mL
25 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ascomycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ascomycin

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Customer Reviews for Ascomycin (1)

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  • The immunosuppressant activity of Ascomycin was studied
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/15/2019
    The immunosuppressant activity of Ascomycin was studied. Analysis of the proteins in iMK1208 against Streptomyces species conducted.
    Ascomycin 4210

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