FK 506

Catalog # Availability Size / Price Qty
3631/10
FK 506 | CAS No. 104987-11-3 | Protein Ser/Thr Phosphatase Inhibitors
1 Image
Description: Potent calcineurin inhibitor; immunosuppressant
Alternative Names: Tacrolimus, Fujimycin

Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

Purity: ≥99%

Product Details
Citations (19)
Supplemental Products
Reviews

Biological Activity

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo.

Analog also available.

Technical Data

M.Wt:
804.02
Formula:
C44H69NO12
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
104987-11-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for FK 506

The citations listed below are publications that use Tocris products. Selected citations for FK 506 include:

19 Citations: Showing 1 - 10

  1. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
    Authors: Chiu Et al.
    Cell Rep  2019;28:332
  2. FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells.
    Authors: Torres Et al.
    Int J Mol Sci  2018;19
  3. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity.
    Authors: Neustadtl Et al.
    Neuroreport  2017;28:618
  4. Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.
    Authors: Henson Et al.
    Neurobiol Learn Mem  2017;138:39
  5. Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle.
    Authors: Sharma Et al.
    Diabetes  2016;65:2606
  6. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Authors: Miyamoto Et al.
    Cell Rep  2016;291:1719
  7. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.
    Authors: Matsa Et al.
    Cell Stem Cell.  2016;19:311
  8. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
    Authors: Palmqvist Et al.
    J Inflamm (Lond)  2016;13:20
  9. Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm.
    Authors: Hadjiasgary Et al.
    J Neurosci  2015;18:130
  10. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
    Authors: Oh Et al.
    Iran J Basic Med Sci  2015;10:162
  11. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling.
    Authors: Codeluppi Et al.
    PLoS One  2014;9:e92649
  12. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    J Biol Chem  2014;7:62
  13. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology  2014;39:569
  14. Different dose-dependent mechanisms are involved in early cyclosp. a-induced cholestatic effects in hepaRG cells.
    Authors: Sharanek Et al.
    Toxicol Sci  2014;141:244
  15. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain.
    Authors: Cai Et al.
    J Pharmacol Exp Ther  2013;345:161
  16. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  17. A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapses.
    Authors: Marra Et al.
    Neuron  2012;76:579
  18. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol.  2012;26:1743
  19. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.
    Authors: Lin Et al.
    Br J Pharmacol  2011;31:1323

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Ascomycin

Reviews for FK 506

There are currently no reviews for this product. Be the first to review FK 506 and earn rewards!

Have you used FK 506?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.