FK 506

Tocris Bioscience | Catalog # 3631

Potent calcineurin inhibitor; immunosuppressant
Tocris Bioscience

Key Product Details

Description

Potent calcineurin inhibitor; immunosuppressant

Alternative Names

Tacrolimus,Fujimycin
View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

FK 506 is a potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Analog also available.

Product Specifications for FK 506

Molecular Weight

804.02

Formula

C44H69NO12

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

CAS Number

104987-11-3

PubChem ID

445643

InChI Key

QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES

O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 80.4 100
Ethanol 80.4 100

Preparing Stock Solutions for FK 506

The following data is based on the product molecular weight 804.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.22 mL 12.44 mL
5 mM 0.25 mL 1.24 mL 2.49 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 140 publications citing the usage of this product.

Product Documents for FK 506

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FK 506

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Customer Reviews for FK 506 (2)

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  • Works as intended.
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    FK506 for PP2B (FK, 1 μM)
    FK 506 3631
  • FK 506, a treatment for primary sclerosing cholangitis
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/25/2019
    FK 506 was tested for its antibiotic properties. FK 506, a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial.
    FK 506 3631

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