FK 506

  ( 15 citations )    
Product Datasheet
Catalog Number:3631
Alternate Names:Tacrolimus, Fujimycin
Chemical Name:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e
Product Details
Citations (15)
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Reviews
Biological Activity
Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo.

Analog also available.

Technical Data
  • M.Wt:
    804.02
  • Formula:
    C44H69NO12
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    104987-11-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for FK 506 include:

15 Citations: Showing 1 - 10
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  1. Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle.
    Authors: Sharma Et al.
    Diabetes  2016;65:2606
  2. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Authors: Miyamoto Et al.
    Cell Rep  2016;291:1719
  3. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.
    Authors: Matsa Et al.
    Cell Stem Cell.  2016;19:311
  4. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
    Authors: Palmqvist Et al.
    J Inflamm (Lond)  2016;13:20
  5. Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm.
    Authors: Hadjiasgary Et al.
    J Neurosci  2015;18:130
  6. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
    Authors: Oh Et al.
    Iran J Basic Med Sci  2015;10:162
  7. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling.
    Authors: Codeluppi Et al.
    PLoS One  2014;9:e92649
  8. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    J Biol Chem  2014;7:62
  9. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology  2014;39:569
  10. Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
    Authors: Sharanek Et al.
    Toxicol Sci  2014;141:244
  11. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain.
    Authors: Cai Et al.
    J Pharmacol Exp Ther  2013;345:161
  12. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  13. A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapses.
    Authors: Marra Et al.
    Neuron  2012;76:579
  14. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol.  2012;26:1743
  15. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.
    Authors: Lin Et al.
    Br J Pharmacol  2011;31:1323
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