ASP 9521

Key Product Details

Product Description

ASP 9521 is a potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC₅₀ = 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cells in vitro. Orally bioavailable.

Product Specifications for ASP 9521

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ASP 9521

The following data is based on the product molecular weight 330.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.26 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kikuchi In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest.New Drugs 2014 PMID: 24981575

Product Documents for ASP 9521