JAK2 inhibitor (IC50
= 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F
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All Tocris products are intended for laboratory research use only.
Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.
Manshouri et al.
Cancer Res., 2011;71:3831
Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.
Quint?s-Cardama et al.
Invest.New Drugs, 2011;29:818