Atiprimod dihydrochloride

Key Product Details

Product Description

Atiprimod dihydrochloride is a JAK2 inhibitor (IC₅₀ = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2^V617F mutation.

Product Specifications for Atiprimod dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Atiprimod dihydrochloride

The following data is based on the product molecular weight 409.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.88 mL	24.42 mL	48.84 mL
2.5 mM	0.98 mL	4.88 mL	9.77 mL
5 mM	0.49 mL	2.44 mL	4.88 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Quintás-Cardama Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 2011 PMID: 20372971
• Manshouri Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 2011 PMID: 21512135

Product Documents for Atiprimod dihydrochloride