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Atiprimod dihydrochloride

Catalog #: 4580 Datasheet / COA / SDS

Discontinued Product

4580 has been discontinued.
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Atiprimod dihydrochloride | CAS No. 130065-61-1 | JAK Kinase Inhibitors
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Description: JAK2 inhibitor

Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride

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Biological Activity

Atiprimod dihydrochloride is a JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Technical Data

M.Wt:
409.52
Formula:
C22H44N2.2HCl
Solubility:
Soluble to 50 mM in water and to 10 mM in DMSO with gentle warming
Storage:
Desiccate at RT
CAS No:
130065-61-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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