Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Biological ActivityMacrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas.
Champney and Burdine
Antimicrob.Agents Chemother., 1995;39:2141
Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution.
Girard et al.
Antimicrob.Agents Chemother., 1987;31:1948
Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.
Retsema et al.
Antimicrob.Agents Chemother., 1987;31:1939
Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex.
Sandeep and McGregor et al.
ChemRxiv - Paper not yet peer reviewed., 2020;
Citations for Azithromycin
The citations listed below are publications that use Tocris products. Selected citations for Azithromycin include:
3 Citations: Showing 1 - 3
Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.
Authors: Groote Et al.
Front Microbiol 2018;9:2231
Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance.
Authors: Palmer Et al.
Mol Biol Evol 2018;35:2669
The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro.
Authors: Broad and Sanger
Br J Pharmacol 2013;168:1859
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Human EFS GI smooth muscle assay