Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Biological ActivityAzithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas.
Champney and Burdine
Antimicrob.Agents Chemother., 1995;39:2141
Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution.
Girard et al.
Antimicrob.Agents Chemother., 1987;31:1948
Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.
Retsema et al.
Antimicrob.Agents Chemother., 1987;31:1939
Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex.
Sandeep and McGregor et al.
ChemRxiv - Paper not yet peer reviewed., 2020;
Citations for Azithromycin
The citations listed below are publications that use Tocris products. Selected citations for Azithromycin include:
3 Citations: Showing 1 - 3
Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.
Authors: Groote Et al.
Front Microbiol 2018;9:2231
Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance.
Authors: Palmer Et al.
Mol Biol Evol 2018;35:2669
The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro.
Authors: Broad and Sanger
Br J Pharmacol 2013;168:1859
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Human EFS GI smooth muscle assay