Azithromycin

Tocris Bioscience | Catalog # 3771

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
Tocris Bioscience

Key Product Details

Description

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Alternative Names

CP 62993
View all DNA, RNA and Protein Synthesis Compounds »

Product Description

Azithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Azithromycin

Molecular Weight

748.98

Formula

C38H72N2O12

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

CAS Number

83905-01-5

PubChem ID

447043

InChI Key

MQTOSJVFKKJCRP-BICOPXKESA-N

SMILES

[H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 74.9 100
Ethanol 74.9 100

Preparing Stock Solutions for Azithromycin

The following data is based on the product molecular weight 748.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.68 mL 13.35 mL
5 mM 0.27 mL 1.34 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for Azithromycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Azithromycin

For research use only

Customer Reviews for Azithromycin (1)

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  • Human tissue pharmacology
    Name: John Broad
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 01/05/2018
    Use at 100-300uM for efficacy as motilin agonist
    Human EFS GI smooth muscle assay
    Azithromycin 3771

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