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Azithromycin | CAS No. 83905-01-5 | DNA, RNA and Protein Synthesis Compounds
1 Image
Description: Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
Alternative Names: CP 62993

Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Purity: ≥99%

Product Details
Citations (3)

Biological Activity

Azithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
  2. Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas.
    Champney and Burdine
    Antimicrob.Agents Chemother., 1995;39:2141
  3. Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution.
    Girard et al.
    Antimicrob.Agents Chemother., 1987;31:1948
  4. Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.
    Retsema et al.
    Antimicrob.Agents Chemother., 1987;31:1939
  5. Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex.
    Sandeep and McGregor et al.
    ChemRxiv - Paper not yet peer reviewed., 2020;

Product Datasheets

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Citations for Azithromycin

The citations listed below are publications that use Tocris products. Selected citations for Azithromycin include:

3 Citations: Showing 1 - 3


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