Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC₅₀ values are 16 - 800 nM) Also potent opioid agonist (IC₅₀ = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Product Specifications for BAM 22P

Molecular Weight

2839.24

Formula

C₁₃₀H₁₈₄N₃₈O₃₁S₂

Storage

Desiccate at -20°C

CAS Number

76622-26-9

PubChem ID

16132339

InChI Key

QYDAFJUKVGVEKO-PKOVDKIBSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Simonin and Kieffer Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 2002 PMID: 11865303
Lembo Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 2002 PMID: 11850634
Mizuno A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 1980 PMID: 7213356
Hong Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 2004 PMID: 14718254

Product Documents for BAM 22P

Certificate of Analysis

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Download SDS

Product Specific Notices for BAM 22P

For research use only

Citations for BAM 22P

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BAM 22P

Tocris Bioscience | Catalog # 1650

Key Product Details

Description

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Product Description