Catalog Number: 1650
Alternate Names: Bovine adrenal medullary peptide-22P, BAM 22 (1-22)
Biological Activity
Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); isolated from bovine adrenal medulla. EC50 values are 13 and 16 nM for human SNSR3 and SNSR4 respectively. Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor.
    Hong et al.
    Br.J.Pharmacol., 2004;141:423
  2. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
    Lembo et al.
    Nat.Neurosci., 2002;5:201
  3. A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.
    Mizuno et al.
    Biochem.Biophys.Res.Commun., 1980;97:1283
  4. Two faces for an opioid peptide - and more receptors for pain research.
    Simonin and Kieffer
    Nat.Neurosci., 2002;5:185

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