Biological ActivityPotent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC50 values are 16 - 800 nM) Also potent opioid agonist (IC50 = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor.
Hong et al.
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
Lembo et al.
A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.
Mizuno et al.
Two faces for an opioid peptide - and more receptors for pain research.
Simonin and Kieffer
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Citation for BAM 22P
The citations listed below are publications that use Tocris products. Selected citations for BAM 22P include:
1 Citation: Showing 1 - 1
Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613
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