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BAM 7

4810 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4810/10
4810/50
Additional Bcl-2 Family Compounds Small Molecule
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Description: Selective Bax activator; induces Bax-mediated apoptosis

Chemical Name: 3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]

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Biological Activity

Bax activator (EC50 = 3.3 μM); binds at the BH3-binding site. Selective for Bax over other antiapoptotic and proapoptotic proteins. Triggers Bax oligomerization in vitro; induces Bax-mediated apoptosis in mouse embryonic fibroblasts.

Technical Data

Formula:
C21H19N5O2S
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
331244-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Direct and selective small-molecule activation of proapoptotic BAX.
    Gavathiotis et al.
    Nat.Chem.Biol., 2012;8:639

Product Datasheets

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