Bay 11-7821

Catalog # Availability Size / Price Qty
Bay 11-7821 | CAS No. 19542-67-7 | Ubiquitin Conjugating Enzyme (E2) Inhibitors
1 Image
Description: E2 ubiquitin (Ub) conjugating enzymes inhibitor
Alternative Names: Bay 11-7082

Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

Purity: ≥99%

Product Details
Citations (8)
Supplemental Products

Biological Activity

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

Technical Data

Soluble to 25 mM in ethanol and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Bay 11-7821

There are currently no reviews for this product. Be the first to review Bay 11-7821 and earn rewards!

Have you used Bay 11-7821?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.