Bay 11-7821

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1744/10
Bay 11-7821 | CAS No. 19542-67-7 | Ubiquitin Conjugating Enzyme (E2) Inhibitors
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Description: E2 ubiquitin (Ub) conjugating enzymes inhibitor
Alternative Names: Bay 11-7082

Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

Purity: ≥99%

Product Details
Citations (8)
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Biological Activity

E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome.

Technical Data

M.Wt:
207.25
Formula:
C10H9NO2S
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
19542-67-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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