Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Biological ActivityE2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
Juliana et al.
Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.
Mori et al.
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.
Strickson et al.
Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce et al.
Gasdermin D (GSDMD) as a new target for the treatment of infection.
Pandeya et al.
Citations for Bay 11-7821
The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7821 include:
8 Citations: Showing 1 - 8
Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.
Authors: Ahn Et al.
J Ginseng Res 2019;43:291
TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling.
Int Immunopharmacol 2017;54:296
Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome.
Authors: Han Et al.
J Ginseng Res 2017;41:513
Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice.
J Neuroinflammation 2017;14(1):207
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer.
Authors: Jia Et al.
Cell Death Differ 2015;22:298
Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One 2014;9:e112989
CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.
Authors: Clement Et al.
Proc Natl Acad Sci U S A 2014;111:E1101
Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexameth. and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells.
Authors: Yang Et al.
J Biol Chem 2011;286:27988
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