Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Biological ActivityE2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
Juliana et al.
Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.
Mori et al.
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.
Strickson et al.
Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce et al.
Citations for Bay 11-7821
The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7821 include:
8 Citations: Showing 1 - 8
Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.
Authors: Ahn Et al.
J Ginseng Res 2019;43:291
TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling.
Int Immunopharmacol 2017;54:296
Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome.
Authors: Han Et al.
J Ginseng Res 2017;41:513
Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice.
J Neuroinflammation 2017;14(1):207
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer.
Authors: Jia Et al.
Cell Death Differ 2015;22:298
Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One 2014;9:e112989
CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.
Authors: Clement Et al.
Proc Natl Acad Sci U S A 2014;111:E1101
Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexameth. and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells.
Authors: Yang Et al.
J Biol Chem 2011;286:27988
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