BAY 293

Catalog # Availability Size / Price Qty
6857/5
BAY 293 | CAS No. 2244904-70-7 | Ras GTPase Inhibitors
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Description: Potent KRas/SOS1 interaction inhibitor

Chemical Name: (R)-6,7-Dimethoxy-2-methyl-N-[1-[4-[2-[(methylamino)methyl]phenyl]thiophene-2-yl]ethyl]quinazolin-4-amine

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent KRas/son of sevenless 1 (SOS1) interaction inhibitor (IC50 = 21 nM); active R-enantiomer. Downregulates active RAS in tumor cells. Inhibits RAS-RAF-MEK-ERK pathway. Exhibits synergistic effects with KRASG12C inhibitor ARS-853.

Technical Data

M.Wt:
448.59
Formula:
C25H28N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2244904-70-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 293 probe summary on the SGC website.
Other Product-Specific Information:

Background References

  1. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
    Hillig et al.
    Proc.Natl.Acad.Sci.USA., 2019;116:2551

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