Catalog Number: 1544
Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Biological Activity
L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. Separate enantiomers (R)-(+)-Bay K 8644 and (S)-(-)-Bay K 8644 also available (Cat. Nos. 1545 and 1546 respectively). In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
    Shi et al.
    Cell Stem Cell, 2008;3:568
  2. Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat.
    Bourson et al.
    Eur.J.Pharmacol., 1989;160:339
  3. Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes.
    Greenberg et al.
    Brain Res., 1984;305:365
  4. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
    Sarkar et al.
    Cell Death Differ., 2009;16:46
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