(±)-Bay K 8644
Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Biological Activity(±)-Bay K 8644 is a L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Shi et al.
Cell Stem Cell., 2008;3:568
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar et al.
Cell Death Differ., 2009;16:46
Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes.
Greenberg et al.
Brain Res., 1984;305:365
Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat.
Bourson et al.
Citations for (±)-Bay K 8644
The citations listed below are publications that use Tocris products. Selected citations for (±)-Bay K 8644 include:
15 Citations: Showing 1 - 10
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
Molecular basis of ancestral vertebrate electroreception.
Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
Front Pharmacol 2016;7:516
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome.
Authors: Cagalinec Et al.
PLoS Biol 2016;14:e1002511
Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
Authors: Sharma Et al.
PLoS One 2016;11:e0163845
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
Circ Heart Fail 2015;10:e0121634
Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Authors: Armstrong and Drapeau
EMBO J 2013;33:1741
TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
Authors: Lee Et al.
J Neurosci 2013;33:1157
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
Authors: Cerignoli Et al.
J Pharmacol Toxicol Methods 2012;66:246
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
Authors: Yang Et al.
J Neurosci 2012;32:7550
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
Authors: Saliba Et al.
PLoS One 2012;31:2937
Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
Authors: Subramanian and Morozov
J Neurosci 2011;31:4755
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Authors: Tian Et al.
Mol Cell Neurosci 2010;44:94
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The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.