(±)-Bay K 8644
Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Biological ActivityL-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Shi et al.
Cell Stem Cell., 2008;3:568
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar et al.
Cell Death Differ., 2009;16:46
Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat.
Bourson et al.
Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes.
Greenberg et al.
Brain Res., 1984;305:365
Citations for (±)-Bay K 8644
The citations listed below are publications that use Tocris products. Selected citations for (±)-Bay K 8644 include:
14 Citations: Showing 1 - 10
Molecular basis of ancestral vertebrate electroreception.
Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
Front Pharmacol 2016;7:516
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome.
Authors: Cagalinec Et al.
PLoS Biol 2016;14:e1002511
Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
Authors: Sharma Et al.
PLoS One 2016;11:e0163845
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
Circ Heart Fail 2015;10:e0121634
Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Authors: Armstrong and Drapeau
EMBO J 2013;33:1741
TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
Authors: Lee Et al.
J Neurosci 2013;33:1157
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
Authors: Cerignoli Et al.
J Pharmacol Toxicol Methods 2012;66:246
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
Authors: Yang Et al.
J Neurosci 2012;32:7550
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
Authors: Saliba Et al.
PLoS One 2012;31:2937
Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
Authors: Subramanian and Morozov
J Neurosci 2011;31:4755
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Authors: Tian Et al.
Mol Cell Neurosci 2010;44:94
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