(±)-Bay K 8644

Catalog # Availability Size / Price Qty
1544/10
1544/50
(±)-Bay K 8644 | CAS No. 71145-03-4 | Cav1.x Channel Activators
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Description: CaV1.x activator

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

(±)-Bay K 8644 is a L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data

M.Wt:
356.3
Formula:
C16H15F3N2O4
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
71145-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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The pharmacological inhibitors for electrophysiology assay
By Anonymous on 02/28/2020
Application: Species: Other

The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.

PMID: 28264196

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