(±)-Bay K 8644

  ( 13 citations )    
Product Datasheet
Catalog Number:1544
Chemical Name:1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Product Details
Citations (13)
Reviews
Biological Activity
L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data
  • M.Wt:
    356.3
  • Formula:
    C16H15F3N2O4
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    71145-03-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-Bay K 8644 include:

13 Citations: Showing 1 - 10
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  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  2. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
    Authors: Ets
    Front Pharmacol  2016;7:516
  3. Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome.
    Authors: Cagalinec Et al.
    PLoS Biol  2016;14:e1002511
  4. Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
    Authors: Sharma Et al.
    PLoS One  2016;11:e0163845
  5. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
    Authors: Mazzuca Et al.
    J Pharmacol Exp Ther  2015;352:291
  6. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Circ Heart Fail  2015;10:e0121634
  7. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    EMBO J  2013;33:1741
  8. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  9. High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
    Authors: Cerignoli Et al.
    J Pharmacol Toxicol Methods  2012;66:246
  10. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
    Authors: Yang Et al.
    J Neurosci  2012;32:7550
  11. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    PLoS One  2012;31:2937
  12. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
    Authors: Subramanian and Morozov
    J Neurosci  2011;31:4755
  13. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
    Authors: Tian Et al.
    Mol Cell Neurosci  2010;44:94
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