(±)-Bay K 8644

Catalog # Availability Size / Price Qty
1544/10
1544/50
Cat.No. 1544 - (�)-Bay K 8644 | C16H15F3N2O4 | CAS No. 71145-03-4
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Description: Ca2+ channel activator (L-type)

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Purity: ≥99%

Product Details
Citations (14)
Reviews

Biological Activity

L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data

M.Wt:
356.3
Formula:
C16H15F3N2O4
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
71145-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (±)-Bay K 8644

The citations listed below are publications that use Tocris products. Selected citations for (±)-Bay K 8644 include:

14 Citations: Showing 1 - 10

  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  2. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
    Authors: Ets
    Front Pharmacol  2016;7:516
  3. Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome.
    Authors: Cagalinec Et al.
    PLoS Biol  2016;14:e1002511
  4. Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
    Authors: Sharma Et al.
    PLoS One  2016;11:e0163845
  5. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
    Authors: Mazzuca Et al.
    J Pharmacol Exp Ther  2015;352:291
  6. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Circ Heart Fail  2015;10:e0121634
  7. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    EMBO J  2013;33:1741
  8. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
    Authors: Lee Et al.
    J Neurosci  2013;33:1157
  9. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  10. High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
    Authors: Cerignoli Et al.
    J Pharmacol Toxicol Methods  2012;66:246

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