(R)-(+)-Bay K 8644

Tocris Bioscience | Catalog # 1545

CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
Tocris Bioscience

Key Product Details

Description

CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
View all Cav1.x Channel Blockers »

Product Description

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Product Specifications for (R)-(+)-Bay K 8644

Molecular Weight

356.30

Formula

C16H15F3N2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

CAS Number

98791-67-4

PubChem ID

6604881

InChI Key

ZFLWDHHVRRZMEI-CYBMUJFWSA-N

SMILES

O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@@H]1[C@]2=CC=CC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.63 100
Ethanol 35.63 100

Preparing Stock Solutions for (R)-(+)-Bay K 8644

The following data is based on the product molecular weight 356.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.40 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for (R)-(+)-Bay K 8644

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-(+)-Bay K 8644

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for (R)-(+)-Bay K 8644

Customer Reviews for (R)-(+)-Bay K 8644 (1)

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  • Test of VGCCs input into 5HT-1B effect on transmembrane current
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    R-(+)-Bay-K (5 μM) was used as a part of a mixture (also containing 1 μM omega -Conotoxin GVIA and 1 μM omega -Agatoxin TK) which blocks voltage-gated calcium channels in a living neuron membrane. Left: the effect of activation of 5HT-1B and AMPA receptors on transmembrane current evoked upon membrane depolarization. Blue trace: control; red trace: 5HT-1B and AMPA receptors activation. Right: block of VGCCs results in 100% suppression of transmembrane current.
    (R)-(+)-Bay K 8644 1545

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