GLP and G9a histone lysine methyltransferase inhibitor (IC50
values are 0.7 and 1.7 μ
M respectively) that displays no activity at other histone methyltransferases up to 37 μ
M. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro
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All Tocris products are intended for laboratory research use only.
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Chang et al.
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Kubicek et al.
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Shi et al.
Cell Stem Cell, 2008;3:568
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.
Malmquist et al.
Proc.Natl.Acad.Sci.U S A, 2012;109:16708
The citations listed below are publications that use Tocris products. Selected citations for BIX 01294 include:
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