values are 0.01, 2.4, 4.3 and 63 μ
M for GSK-3α
, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Soluble to 20 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Polychronopoulos et al.
Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells.
Gattinoni et al.
GSK-3-selective inhibitors derived from tyrian purple indirubins.
Meijer et al.
The citations listed below are publications that use Tocris products. Selected citations for BIO-acetoxime include:
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