Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Biological ActivitySelective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
GSK-3-selective inhibitors derived from tyrian purple indirubins.
Meijer et al.
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Polychronopoulos et al.
Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells.
Gattinoni et al.
Citations for BIO-acetoxime
The citations listed below are publications that use Tocris products. Selected citations for BIO-acetoxime include:
2 Citations: Showing 1 - 2
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.
Authors: Shi Et al.
Cell Stem Cell 2017;20:675
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
Authors: Penas Et al.
Sci Rep 2015;14:417
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