Catalog Number: 3874
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Biological Activity
Selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Technical Data
  • M.Wt:
    398.21
  • Formula:
    C18H12BrN3O3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    667463-85-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
    Polychronopoulos et al.
    J.Med.Chem., 2004;47:935
  2. Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells.
    Gattinoni et al.
    Nat.Med., 2009;15:808
  3. GSK-3-selective inhibitors derived from tyrian purple indirubins.
    Meijer et al.
    Chem.Biol., 2003;10:1255
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BIO-acetoxime include:

1 Citations: Showing 1 - 1

  1. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
    Authors: Penas Et al.
    Sci Rep 2015;14:417

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