Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC)

Discontinued Product

S-300 has been discontinued.
View all Proteasome Substrates products.
Product Details
Citations (8)
Reviews (2)

Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC) Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Citations for Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system
    Authors: V Røyseth, BM Hurysz, A Kaczorowsk, S Dorawa, AE Fedøy, H Arsin, M Serafim, O Werbowy, T Kaczorowsk, R Stokke, AJ O'Donoghue, IH Steen
    bioRxiv : the preprint server for biology, 2023-04-04;0(0):.  2023-04-04
  2. Differential Effects of Nonsteroidal Anti-Inflammatory Drugs in an In Vitro Model of Human Leaky Gut
    Authors: M d'Angelo, L Brandolini, M Catanesi, V Castelli, C Giorgio, M Alfonsetti, M Tomassetti, M Zippoli, E Benedetti, MC Cesta, S Colagioia, P Cocchiaro, A Cimini, M Allegretti
    Cells, 2023-02-24;12(5):.  2023-02-24
  3. Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells
    Authors: X Lan, M Hu, L Jiang, J Wang, Y Meng, X Chen, A Liu, W Ding, H Zhang, H Zhou, B Liu, G Peng, S Liao, X Chen, J Liu, X Shi
    Journal of ethnopharmacology, 2022-10-08;301(0):115815.  2022-10-08
  4. Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition
    Authors: T Hirano, N Suzuki, Y Ikenaka, N Hoshi, Y Tabuchi
    Toxicology and Applied Pharmacology, 2021-09-11;430(0):115723.  2021-09-11
  5. NSAIDs-dependent adaption of the mitochondria-proteasome system in immortalized human cardiomyocytes
    Authors: L Brandolini, A Antonosant, C Giorgio, M Bagnasco, M d'Angelo, V Castelli, E Benedetti, A Cimini, M Allegretti
    Sci Rep, 2020-10-27;10(1):18337.  2020-10-27
  6. A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth
    Authors: X Li, Q Huang, H Long, P Zhang, H Su, J Liu
    EBioMedicine, 2018-12-05;0(0):.  2018-12-05
  7. Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation
    Authors: X Lan, C Zhao, X Chen, P Zhang, D Zang, J Wu, J Chen, H Long, L Yang, H Huang, X Wang, X Shi, J Liu
    Cell Death Dis, 2017-07-06;8(7):e2913.  2017-07-06
  8. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum
    Authors: M Ye, H Qiu, Y Cao, M Zhang, Y Mi
    Front. Pharmacol, 2017-03-21;8(0):148.  2017-03-21


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Reviews for Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC)

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Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC)
By TAKASHI SHIMADA on 05/02/2020

S-300 hydrolysis confirmation by LCMS-SRM
S-300: 1 uM
i20S: 15 nM
PA28a: 150 nM
Reaction: 37 °C for 5 h
1:S-300 Boc-LRR-AMC (351.20>301.30)
2:Free AMC (176.25>120.00)
3:S-300 Boc-LRR-COOH (272.70>222.15)

Boc-Leu-Arg-Arg-AMC (Boc-LRR-AMC)
By TAKASHI SHIMADA on 05/01/2020

Ordinate: fluorescent count, Em 345/Ex 445
Em band path: 9 nm
Ex band path: 20 nm
Horizontal: time [sec]
Temp: 37 °C
S-300: 20 nM
Trypsin: 10 ng per assay (100 uL)
T1-T6: S-300/Trypsin (N=6)
Sub: S-300 and Tris buffer
Buffer: Tris buffer only
S-300 has very low level of intrinsic fluorescence but does not interfere the sample assay.