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BPDE Antibody

Catalog #: 4360-MC-100
2 Citations Datasheet / COA / SDS

Discontinued Product

4360-MC-100 has been discontinued.
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Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

BPDE Antibody Summary

Specificity
The antibody recognizes both free polycyclic aromatic hydrocarbons (PAHs) and DNA adducts.
Source
Monoclonal Mouse IgG1 Clone # 8E11
Purification
Protein A or G purified from ascites
Immunogen
BPDE-I-G coupled to BSA
Formulation
This antibody is provided from mouse ascites, provided at 1 mg/ml in PBS, 50% glycerol.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Competitive ELISA
In an inhibition assay, the binding of the antibody to BPDE adducts was inhibited by BPDE-I-DNA, BPDE-I-dG, BPDE-I tetraol but not by BPDE-II-DNA.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Stored at -20 °C. For long term storage, freeze in working aliquots at -20 °C in a manual defrost freezer to avoid repeated freeze-thawings.

Background: BPDE

The antibody may be used to investigate exposure to environmental and occupational pollutants. PAHs are released into the environment following incomplete combustion of organic materials. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Exposure to this group of compounds is believed to be carcinogenic.

Long Name
Benzo[A] Pyrene-Diol Epoxide
Alternate Names
Benzo Pyrene Dihydrodiol Epoxide; BPDE

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Citations for BPDE Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Genome-wide mapping of nucleotide excision repair with XR-seq
    Authors: J Hu, W Li, O Adebali, Y Yang, O Oztas, CP Selby, A Sancar
    Nat Protoc, 2019-01-01;14(1):248-282.
    Applications: Immunoprecipitation
  2. Exposure to heavy metals and polycyclic aromatic hydrocarbons and DNA damage in taiwanese traffic conductors.
    Authors: Huang H, Chen G, Wang C, Lin Y, Liou S, Lai C, Wang S
    Cancer Epidemiol Biomarkers Prev, 2012-11-13;22(1):102-8.

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