BRD 4354

Key Product Details

Product Description

BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC₅₀ values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC₅₀ values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Product Specifications for BRD 4354

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BRD 4354

The following data is based on the product molecular weight 382.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.22 mL	26.12 mL	52.23 mL
2.5 mM	1.04 mL	5.22 mL	10.45 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
25 mM	0.10 mL	0.52 mL	1.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Boskovic Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 2016 PMID: 27064299

Product Documents for BRD 4354