Home / Class I Histone Deacetylases Inhibitors / BRD 4354

BRD 4354

Catalog #: 6010 Datasheet / COA / SDS

Discontinued Product

6010 has been discontinued.
View all Class I Histone Deacetylases Inhibitors products.
BRD 4354 | CAS No. 315698-07-8 | Class I Histone Deacetylases Inhibitors
1 Image
Description: HDAC5 and HDAC9 inhibitor

Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Technical Data

M.Wt:
382.89
Formula:
C21H23ClN4O
Solubility:
Soluble to 20 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
315698-07-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile.
    Boskovic et al.
    ACS Chem.Biol., 2016;11:1844

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BRD 4354

There are currently no reviews for this product. Be the first to review BRD 4354 and earn rewards!

Have you used BRD 4354?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.