Chemical Name: N-Hydroxy-1-cyclopentene-1-carboxamide
Biological ActivityPotent and selective HDAC6 inhibitor (IC50 = 30 nM). Displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
Wagner et al.
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