Catalog Number: 1663
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide
Biological Activity
Potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice.
    Broom et al.
    J.Pharmacol.Exp.Ther., 2002;303:723
  2. A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.
    Chang et al.
    J.Pharmacol.Exp.Ther., 1993;267:852
  3. A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration.
    Dykstra et al.
    J.Pharmacol.Exp.Ther., 1993;267:875

The citations listed below are publications that use Tocris products. Selected citations for BW 373U86 include:

Showing Results 1 - 1 of 1

  1. Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats.
    Authors: Donner Et al.
    J Allergy Clin Immunol
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