BW 373U86
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide
Purity: ≥99%
Biological Activity
BW 373U86 is a potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice.
Broom et al.
J.Pharmacol.Exp.Ther., 2002;303:723 -
A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.
Chang et al.
J.Pharmacol.Exp.Ther., 1993;267:852 -
A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration.
Dykstra et al.
J.Pharmacol.Exp.Ther., 1993;267:875
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Citation for BW 373U86
The citations listed below are publications that use Tocris products. Selected citations for BW 373U86 include:
1 Citation: Showing 1 - 1
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Obesity improves myocardial ischaemic tolerance and RISK signalling in Ins-insensitive rats.
Authors: Donner Et al.
J Allergy Clin Immunol 2013;6:457
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