Catalog Number: 1059
Chemical Name: α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride
Biological Activity
Selective 5-HT2B receptor agonist.
Technical Data
  • M.Wt:
    322.85
  • Formula:
    C16H18N2OS.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    160521-72-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.
    Kennett et al.
    Neuropharmacology, 1997;36:233
  2. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated.
    Kennett et al.
    Neuropharmacology, 1998;37:1603
  3. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Niebert et al.
    PLoS One, 2011;6:e21395
  4. Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat.
    Duxon et al.
    Neuropharmacology, 1997;36:601
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BW 723C86 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    PLoS One 2015;3:e00103
  2. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  3. Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
    Authors: Hernandez Et al.
    Pharmacol Res Perspect 2012;302:E1009
  4. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Authors: Niebert Et al.
    J Pharmacol Exp Ther 2011;6:e21395
  5. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B.
    Authors: Wouters Et al.
    J Biol Chem 2009;284:21177

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