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C-1

Catalog #: 0543 Datasheet / COA / SDS

Discontinued Product

0543 has been discontinued.
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C-1 | CAS No. 84468-24-6 | Protein Kinase C Inhibitors
1 Image
Description: Inhibits PKG, PKA and PKC
Alternative Names: HA 100

Chemical Name: 1-(5-Isoquinolinesulfonyl)piperazine

Purity: ≥99%

Product Details
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

C-1 is a protein kinase inhibitor. Inhibits PKG, PKA and PKC (IC50 values are 4, 8 and 12 μM, respectively). Widely used as a ROCK inhibitor. Increases efficiency of human fibroblast reprogramming with PD 0325901 (Cat.No 4192), CHIR 99021 (Cat.No 4432), A 83-01 (Cat.No 2939) and hLIF. Improves survival of human pluripotent stem cells in culture.

Technical Data

M.Wt:
277.34
Formula:
C13H15N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
84468-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  3. Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidation metabolism by various agonists.
    Gerard et al.
    J.Clin.Invest., 1986;77:61
  4. Efficient feeder-free episomal reprogramming with small molecules.
    Yu et al.
    PLoS.One., 2011;6:e17557
  5. Chemically defined conditions for human iPSC derivation and culture.
    Chen et al.
    Nat.Methods, 2011;8:424

Product Datasheets

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