Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50
values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors. In combination with tranylcypromine
(Cat. No. 3852), enables reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901
(Cat. No. 4192).
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li et al.
Stem Cells, 2009;27:2992
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Pan et al.
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Ring et al.
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains.
Ye et al.
PLoS One, 2012;7:e35892
The citations listed below are publications that use Tocris products. Selected citations for CHIR 99021 include:
Showing Results 1 - 10 of 31