A 83-01

  ( 30 citations )    
Product Datasheet
Catalog Number:2939
Chemical Name:3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Product Details
Citations (30)
Supplemental Products
Reviews
Biological Activity
Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.
Technical Data
  • M.Wt:
    421.52
  • Formula:
    C25H19N5S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    909910-43-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 83-01 include:

30 Citations: Showing 1 - 10
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  1. CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency.
    Authors: Liu Et al.
    Cell Stem Cell.  2018;22:252
  2. Enhanced Development of Skeletal Myotubes from Porcine Induced Pluripotent Stem Cells.
    Authors: Genovese
    Sci Rep  2017;7:41833
  3. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  4. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell  2016;18(653)
  5. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.
    Authors: Foulke-Abel Et al.
    Nat Protoc  2016;150:638
  6. Organoid culture systems for prostate epithelial and cancer tissue.
    Authors: Drost Et al.
    Proc Natl Acad Sci U S A  2016;11:347
  7. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
    Authors: Zhao Et al.
    Nat Commun  2015;6:8243
  8. Amnion cell mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response.
    Authors: Tan Et al.
    Stem Cell Res Ther  2015;6:8
  9. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
    Authors: Nantasanti Et al.
    Stem Cell Res  2015;5:895
  10. CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
    Authors: Kido Et al.
    Inflamm Bowel Dis  2015;5:508
  11. Transcription factor binding dynamics during human ES cell differentiation.
    Authors: Tsankov Et al.
    Stem Cell Reports  2015;518:344
  12. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
    Authors: Liao Et al.
    Cell  2015;47:469
  13. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Nat Genet  2015;330:29
  14. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
    Authors: Mattis Et al.
    Exp Cell Res  2015;24:3257
  15. Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.
    Authors: Sibony Et al.
    Proc Natl Acad Sci U S A  2015;21:2778
  16. Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.
    Authors: Dai Et al.
    Stem Cells Int  2015;2014:182737
  17. Organoid models of human and mouse ductal pancreatic cancer.
    Authors: Boj Et al.
    Cell  2015;160:324
  18. Long-term culture of genome-stable bipotent stem cells from adult human liver.
    Authors: Huch Et al.
    Nature  2015;160:299
  19. Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure.
    Authors: Yang Et al.
    Stem Cell Reports  2015;112:E2337
  20. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
    Authors: Weeber Et al.
    Hum Mol Genet  2015;112:13308
  21. β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.
    Authors: Corritore Et al.
    Cell Cycle  2014;16:456
  22. Mechanism-based corrector combination restores δF508-CFTR folding and function.
    Authors: Okiyoneda Et al.
    Nat Chem Biol  2013;9:444
  23. Generation of BAC transgenic epithelial organoids.
    Authors: Schwank Et al.
    Cell Reprogram  2013;8:e76871
  24. An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.
    Authors: Yanagida Et al.
    PLoS One  2013;8:e67541
  25. High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.
    Authors: O'Malley Et al.
    Nature  2013;499:88
  26. Immunosurveillance against tetraploidization-induced colon tumorigenesis.
    Authors: Boilàve Et al.
    Proc Natl Acad Sci U S A  2013;12:473
  27. Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.
    Authors: Kearns Et al.
    PLoS One  2013;11:1003
  28. Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.
    Authors: Hirschhorn Et al.
    PLoS One  2012;7:e43459
  29. Porcine induced pluripotent stem cells analogous to naïve and primed embryonic stem cells of the mouse.
    Authors: Telugu Et al.
    Int J Dev Biol  2011;54:1703
  30. Generation of genetically modified rats from embryonic stem cells.
    Authors: Kawamata and Ochiya
    Nature  2010;107:14223
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