c-Di-AMP sodium salt

Tocris Bioscience | Catalog # 5901

Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Tocris Bioscience
Discontinued Product
5901 has been discontinued. View all STING-dependent Signaling Antagonists products.

Key Product Details

Description

Endogenous STING and DDX41 agonist; activates STING-dependent signaling
View all STING-dependent Signaling Antagonists »

Product Description

c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.

This product is sold in units of 702μg, equivalent to 1μmol.

Product Specifications for c-Di-AMP sodium salt

Molecular Weight

702.38

Formula

C20H22N10Na2O12P2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3',5'-Cyclic diadenylic acid sodium salt

CAS Number

2734909-87-4

PubChem ID

11158091

InChI Key

PDXMFTWFFKBFIN-XPWFQUROSA-N

SMILES

O=P(O[C@H]1[C@H]([C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO4)O)(O[Na])OC[C@@H]5[C@H]([C@H]([C@H](N6C=NC7=C6N=CN=C7N)O5)O)OP4(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.05 20

Preparing Stock Solutions for c-Di-AMP sodium salt

The following data is based on the product molecular weight 702.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.12 mL 35.59 mL 71.19 mL
1 mM 1.42 mL 7.12 mL 14.24 mL
2 mM 0.71 mL 3.56 mL 7.12 mL
10 mM 0.14 mL 0.71 mL 1.42 mL

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Product Documents for c-Di-AMP sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for c-Di-AMP sodium salt

For research use only

Related Research Areas

Interferons

Customer Reviews for c-Di-AMP sodium salt (1)

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  • Induction of type I IFNs with c-di-AMP in different cell lines
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 08/19/2019
    Make sure to resuspend c-di-AMP and stimulate cells with 1-100 mg/ml c-di-AMP for 16-48 hours. Monitor induction of type I IFNs by measuring the levels of IRF-induced Lucia luciferase in the cell culture supernatant
    Induction of type I IFNs with c-di-AMP was studied in a variety of cell lines. The human monocytic cell line THP-1 has been shown to express all the CDSs4-6 with the exception of DAI.
    c-Di-AMP sodium salt 5901

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