Catalog Number: 4799
Alternate Names: Ro 09-1978
Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Biological Activity
Prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
    Shimma et al.
    Bioorg.Med.Chem.Lett., 2000;8:1697
  2. Metabolism of capecitabine, an oral fluorouracil prodrug: 19F NMR studies in animal models and human urine.
    Desmoulin et al.
    Drug Metab.Dispos., 2002;30:1221
  3. Cell cycle phase specificity of antitumor agents.
    Bhuyan et al.
    Cancer Res., 1972;32:398
Tocris Small Molecules
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