Capecitabine

Tocris Bioscience | Catalog # 4799

Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
Tocris Bioscience
Discontinued Product
4799 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description

Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis

Alternative Names

Ro 09-1978
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.

Product Specifications for Capecitabine

Molecular Weight

359.35

Formula

C15H22FN3O6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

CAS Number

154361-50-9

PubChem ID

60953

InChI Key

GAGWJHPBXLXJQN-UORFTKCHSA-N

SMILES

C[C@H]1O[C@@H](N2C=C(F)C(NC(OCCCCC)=O)=NC2=O)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.94 100
Ethanol 35.94 100

Preparing Stock Solutions for Capecitabine

The following data is based on the product molecular weight 359.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Capecitabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Capecitabine

For research use only

Customer Reviews for Capecitabine (1)

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  • Medium concentrations of capecitabine only weakly slow melanoma growth in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    Capecitabine 4799

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