Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Biological ActivityProdrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Shimma et al.
Cell cycle phase specificity of antitumor agents.
Bhuyan et al.
Cancer Res., 1972;32:398
Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine.
Desmoulin et al.
Drug Metab.Dispos., 2002;30:1221
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Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.