Capecitabine
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Description: Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
Alternative Names: Ro 09-1978
Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Purity: ≥98%
Biological Activity
Prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.Technical Data
M.Wt:
359.35
Formula:
C15H22FN3O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
154361-50-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Shimma et al.
Bioorg.Med.Chem.Lett., 2000;8:1697 -
Metabolism of capecitabine, an oral fluorouracil prodrug: 19F NMR studies in animal models and human urine.
Desmoulin et al.
Drug Metab.Dispos., 2002;30:1221 -
Cell cycle phase specificity of antitumor agents.
Bhuyan et al.
Cancer Res., 1972;32:398
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