Catalog Number: 0744
Chemical Name: N-Acetylsphingosine
Biological Activity
A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ceramide stimulates a cytosolic protein phosphatase.
    Dobowsky and Hannun
    J.Biol.Chem., 1992;267:5048
  2. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon.
    Kim et al.
    J.Biol.Chem., 1991;266:484
  3. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation.
    Quintans et al.
    Biochem.Biophys.Res.Commun., 1994;202:710
  4. Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.
    Xie and Johnson
    J.Neurochem., 1997;69:1020

The citations listed below are publications that use Tocris products. Selected citations for Ceramide include:

1 Citations: Showing 1 - 1

  1. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
    Authors: Samokhvalov Et al.
    Pharmacol Biochem Behav 2015;232:44105

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