A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro
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Ceramide stimulates a cytosolic protein phosphatase.
Dobowsky and Hannun
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon.
Kim et al.
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation.
Quintans et al.
Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.
Xie and Johnson
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