cGMP Dependent Kinase Inhibitor Peptide
Biological ActivityCompetitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.
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Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates.
Bhatnagar et al.
Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors.
Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein.
Glass et al.
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We examined the regulatory mechanism of the PKG holoenzymes. The development of cGMP-independent peptide activators of PKG I alpha, derived from this helical segment was found bridging the regulatory and catalytic domains.