cGMP Dependent Kinase Inhibitor Peptide
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Description: Inhibitor of protein kinases G and A
Alternative Names: [Ala32]H2B(29-35)
Biological Activity
cGMP Dependent Kinase Inhibitor Peptide is a competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.Technical Data
M.Wt:
943.12
Formula:
C38H74N18O10
Sequence:
RKRARKE
Storage:
Desiccate at -20°C
CAS No:
82801-73-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates.
Bhatnagar et al.
Biochemistry, 1988;27:1988 -
Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors.
Glass
Biochem.J., 1983;213:159 -
Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein.
Glass et al.
J.Biol.Chem., 1986;261:12166
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