Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Biological ActivityCalmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity.
Norman et al.
Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor.
Neuhaus and Reber
Calmodulin regulates the transcriptional activity of estrogen receptors.
Li et al.
Citations for CGS 9343B
The citations listed below are publications that use Tocris products. Selected citations for CGS 9343B include:
2 Citations: Showing 1 - 2
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Authors: Haag Et al.
Cell Rep 2018;24:2418
The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Authors: Hou Et al.
Eur J Immunol 2015;13:e1002233
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CGS 9343B
There are currently no reviews for this product. Be the first to review CGS 9343B and earn rewards!
Have you used CGS 9343B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image