CGS 9343B

Key Product Details

Product Description

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC₅₀ of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

Product Specifications for CGS 9343B

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGS 9343B

The following data is based on the product molecular weight 544.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.67 mL	18.36 mL	36.72 mL
2.5 mM	0.73 mL	3.67 mL	7.34 mL
5 mM	0.37 mL	1.84 mL	3.67 mL
25 mM	0.07 mL	0.37 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Neuhaus and Reber Inhibition of membrane currents and rises of intracellular Ca²⁺ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 1992 PMID: 1379190
• Li Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 2003 PMID: 12419798
• Norman CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 1987 PMID: 3033469

Product Documents for CGS 9343B