Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Biological ActivityCGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity.
Norman et al.
Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor.
Neuhaus and Reber
Calmodulin regulates the transcriptional activity of estrogen receptors.
Li et al.
Citations for CGS 9343B
The citations listed below are publications that use Tocris products. Selected citations for CGS 9343B include:
2 Citations: Showing 1 - 2
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Authors: Haag Et al.
Cell Rep 2018;24:2418
The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Authors: Hou Et al.
Eur J Immunol 2015;13:e1002233
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