Catalog Number: 2255
Alternate Names: Zaldaride maleate
Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Biological Activity
Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
Technical Data
  • M.Wt:
    544.61
  • Formula:
    C26H28N4O2.C4H4O4
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    109826-27-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity.
    Norman et al.
    Mol.Pharmacol., 1987;31:535
  2. Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor.
    Neuhaus and Reber
    Eur.J.Pharmacol., 1992;226:183
  3. Calmodulin regulates the transcriptional activity of estrogen receptors.
    Li et al.
    J.Biol.Chem., 2003;278:1195
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGS 9343B include:

1 Citations: Showing 1 - 1

  1. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
    Authors: Hou Et al.
    Eur J Immunol 2015;13:e1002233

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