Selective agonist at PPARγ
(peroxisome proliferator-activated receptor γ
). Activates PPARγ
with an EC50
value of 3 μ
M in vitro
, and is at least 33-fold selective over PPARα
. Antihyperglycemic in vivo
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Thiazolidinediones - the new insulin enhancers.
Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo.
Xin et al.
The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
Willson et al.