Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Biological ActivityCiglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Thiazolidinediones - the new Ins enhancers.
The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones.
Willson et al.
Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo.
Xin et al.
Citations for Ciglitazone
The citations listed below are publications that use Tocris products. Selected citations for Ciglitazone include:
2 Citations: Showing 1 - 2
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).
Authors: Zeitouni Et al.
BMC Biotechnol 2008;8:75
Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression.
Authors: Emmans Et al.
Biochem Soc Trans 2004;32:840
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