Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50
= 7 μ
M) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman et al.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone et al.
The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:
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