Catalog Number: 4529
Alternate Names: HPI-4
Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Biological Activity
Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
Technical Data
  • M.Wt:
    358.18
  • Formula:
    C17H9Cl2N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    302803-72-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman et al.
    Proc.Natl.Acad.Sci.USA, 2009;106:14132
  2. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
    Firestone et al.
    Nature, 2012;484:7392
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:

1 Citations: Showing 1 - 1

  1. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
    Authors: Shin Et al.
    Biomol Ther (Seoul) 2015;23:327

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