Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Biological ActivityHedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman et al.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone et al.
Citations for Ciliobrevin A
The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:
3 Citations: Showing 1 - 3
Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins.
Authors: Poon Et al.
Nat Commun 2019;10:3779
ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments.
Authors: Conzemius Et al.
J Virol 2016;90:7934
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
Authors: Shin Et al.
Biomol Ther (Seoul) 2015;23:327
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