Ciliobrevin A

Catalog # Availability Size / Price Qty
4529/25
4529/5
Ciliobrevin A | CAS No. 302803-72-1 | Hedgehog Signaling Inhibitors
1 Image
Description: Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
Alternative Names: HPI-4

Chemical Name: 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews

Biological Activity

Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

Technical Data

M.Wt:
358.18
Formula:
C17H9Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
302803-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
    Hyman et al.
    Proc.Natl.Acad.Sci.USA, 2009;106:14132
  2. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
    Firestone et al.
    Nature, 2012;484:7392

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Ciliobrevin A

The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:

3 Citations: Showing 1 - 3

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ciliobrevin A

There are currently no reviews for this product. Be the first to review Ciliobrevin A and earn rewards!

Have you used Ciliobrevin A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.