Ciliobrevin A

  ( 2 citations )    
Product Datasheet
Catalog Number:4529
Alternate Names:HPI-4
Chemical Name:2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
Technical Data
  • M.Wt:
    358.18
  • Formula:
    C17H9Cl2N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    302803-72-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ciliobrevin A include:

2 Citations: Showing 1 - 2
Filter your results:

  1. ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments.
    Authors: Conzemius Et al.
    J Virol  2016;90:7934
  2. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
    Authors: Shin Et al.
    Biomol Ther (Seoul)  2015;23:327

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Ciliobrevin A?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee