Cimetidine (CAS 51481-61-9): R&D Systems
Catalog Number: 0902
Chemical Name: N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
Biological Activity
Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand.
Technical Data
  • M.Wt:
    252.34
  • Formula:
    C10H16N6S
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    51481-61-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distribution, properties and functional characteristics of three classes of histamine receptor.
    Hill
    Pharmacol.Rev., 1990;42:45
  2. The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of langerhans.
    Tsoli et al.
    Eur.J.Pharmacol., 1995;284:199
  3. Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active receptors.
    Smit et al.
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:6802
  4. A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors.
    Ernsberger et al.
    J.Cardiovasc.Pharmacol., 1992;20:S1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cimetidine include:

4 Citations: Showing 1 - 4
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  1. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol 2015;18
  2. Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.
    Authors: Wang Et al.
    J Neurosci 2014;3:1126
  3. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
    Authors: Francis Et al.
    Gut 2012;61:753
  4. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
    Authors: Strait Et al.
    J Clin Invest 2006;116:833

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