Catalog Number: 2295
Chemical Name: (5Z)-rel-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid monosodium salt
Biological Activity
Water-soluble prostaglandin F2α (PGF2α) analog; acts as a potent FP receptor agonist (EC50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo.
Technical Data
  • M.Wt:
    446.9
  • Formula:
    C22H28ClNaO6
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    55028-72-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent luteolytic agents related to prostaglandin F.
    Dukes et al.
    Nature, 1974;250:330
  2. Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization.
    Griffin et al.
    J.Pharmacol.Exp.Ther., 1998;286:411
  3. Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium.
    Serrero and Lepak
    Biochem.Biophys.Res.Comm., 2002;233:200

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