Chemical Name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Biological ActivityBroad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.
Ilyin et al.
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
Ilyin et al.
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