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Cocaine hydrochloride

Catalog #: 2833
3 Citations Datasheet / COA / SDS

Discontinued Product

2833 has been discontinued.
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Cocaine hydrochloride | CAS No. 53-21-4 | Dopamine Transporter Inhibitors
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Description: Inhibitor of monoamine transporters

Chemical Name: 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.

Technical Data

M.Wt:
339.81
Formula:
C17H21NO4.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
53-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors.
    Yuan T, Mameli M, O' Connor E, Dey P, Verpelli C, Sala C, Perez-Otano I, Luscher C, Bellone C
    Neuron, 2013;80(4):1025-38.
  2. Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity.
    Fleckenstein et al.
    Eur.J.Pharmacol., 2000;406:1
  3. Plasma membrane monoamine transporters: structure, regulation and function.
    Torres et al.
    Nat.Rev.Neurosci., 2003;4:13

Product Datasheets

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Citations for Cocaine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Cocaine hydrochloride include:

3 Citations: Showing 1 - 3

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  2. A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    Neuropsychopharmacology  2012;37:1856
  3. Spike timing-dependent long-term potentiation in ventral tegmental area DA cells requires PKC.
    Authors: Luu and Malenka
    J Neurophysiol  2008;100:533

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