Cocaine hydrochloride

Tocris Bioscience | Catalog # 2833

Inhibitor of monoamine transporters
Tocris Bioscience
Discontinued Product
2833 has been discontinued. View all Dopamine Transporter Inhibitors products.

Key Product Details

Description

Inhibitor of monoamine transporters
View all Dopamine Transporter Inhibitors »

Product Description

Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.

Product Specifications for Cocaine hydrochloride

Molecular Weight

339.81

Formula

C17H21NO4.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride

CAS Number

53-21-4

PubChem ID

656832

InChI Key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

SMILES

O=C(C3=CC=CC=C3)O[C@@H]2[C@H]([C@](OC)=O)[C@@]1([H])CC[C@](C2)([H])N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.98 100

Preparing Stock Solutions for Cocaine hydrochloride

The following data is based on the product molecular weight 339.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.71 mL 29.43 mL
5 mM 0.59 mL 2.94 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for Cocaine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cocaine hydrochloride

For research use only

Citations for Cocaine hydrochloride

Customer Reviews for Cocaine hydrochloride (1)

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  • Chronic restraint stress during withdrawal increases vulnerability to drug priming-induced cocaine seeking
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/28/2019
    We tested the effect of chronic restraint stress on cocaine seeking in rats using both extinction- and abstinence-based animal relapse models. Rats were trained to press a lever for I.V. cocaine infusions (0.50 mg/kg/infusion) paired with a discrete tone+light cue in daily 3-h sessions. A main finding was that a history of chronic restraint stress was associated with increased cocaine priming-induced drug seeking.
    Cocaine hydrochloride 2833

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